POINT-OF-CARE QUANTUM DOT DIAGNOSTIC DEVICE

Trade Agreement: Agreement on Internal Trade (AIT) Tendering Procedures: All interested suppliers may submit a bid Attachment: None Competitive Procurement Strategy: Best Overall Proposal Comprehensive Land Claim Agreement: No Nature of Requirements: TITLE

POINT-OF-CARE QUANTUM DOT DIAGNOSTIC DEVICE FOR THE MULTIPLEXED IDENTIFICATION OF DISEASE PATHOGENS AND BIOLOGICAL THREAT AGENTS

REQUIREMENT

Defence Research and Development (R&D) Canada (DRDC), an agency of the Department of National Defence (DND), has a requirement to demonstrate and deliver a rapid hand-held point-of-care (PoC) in vitro diagnostic device (IVDD) employing quantum dot (QD) nanotechnology for the simultaneous (multiplexed) identification of both endemic disease pathogens and biological threat agents in a single sample. This device must be usable as an early-symptomatic treatment decision support tool by Canadian Forces (CF) personnel on deployment.

The project will demonstrate a QD hand-held, diagnostic tool, capable of multiplexed analysis of samples, i.e., capable of detecting multiple pathogens, including both endemic and biological warfare (BW) threat agents, in a single clinical sample of biological origin (e.g., blood). This QD technology will enable the CF to rapidly identify viral, bacterial, and parasitic agents leading to presumptive diagnoses, assisting with determining treatment regimens and with epidemiological analyses. PoC diagnostics will provide a capability for limiting the effects of a contagious illness and reducing, and possibly eliminating, morbidity and mortality through earlier use of prophylaxis and treatment. The QD diagnostic device to be developed under this project will be beneficial in operational scenarios involving:

Short notice deployment to regions harboring endemic disease where little medical support is available; Deployment to regions where there is a threat of, or actual, BW agent use; Repatriation of possibly infected deployed personnel; and Assistance to the civil authority for biological public health threats.

The Contractor will be required to do the following

Develop and demonstrate a proof-of-concept, QD, hand-held, PoC device capable of the simultaneous identification of multiple targets (Anthrax protective antigen, differentiate between past and current exposure to dengue fever virus (serotypes 1-4), and malaria (differentiating exposure to Plasmodium falciparum versus exposure to other Plasmodium spp.)) in a blood sample. Develop and demonstrate a prototype QD PoC diagnostic device that meets all of the required physical and performance specifications. Design and conduct a complete laboratory trial and an end user trial for the prototype QD PoC diagnostic device. Complete all required documentation to seek Health Canada Investigational Testing Approval for an in vitro diagnostic device.

The period of the Contract is for 42 months from date of Contract.

The requirement is subject to the provisions of the Agreement on Internal Trade (AIT).

All interested suppliers may submit a bid.

EVALUATION PROCEDURES

Bids will be assessed in accordance with the entire requirement of the bid solicitation including the mandatory and point rated technical evaluation criteria.

MANDATORY TECHNICAL CRITERIA

At bid closing time, the Bidder must comply with the following mandatory technical criteria and provide the necessary documentation to support compliance. Any bid which fails to meet the following mandatory technical criteria will be declared non-responsive. Each criterion should be addressed separately.

Mandatory technical evaluation criteria are included in Attachment 3 of the bid solicitation.

POINT RATED TECHNICAL EVALUATION CRITERIA

Point rated technical evaluation criteria are included in Attachment 3 of the bid solicitation.

SELECTION METHOD

To be declared responsive, a bid must

(a) comply with all the requirements of the bid solicitation;

(b) meet all mandatory technical evaluation criteria;

(c) obtain the required minimum points overall for the technical evaluation criteria which are subject to point rating.

Bids not meeting (a) or (b) or (c) will be declared nonresponsive.

The responsive bid with the highest number of points will be recommended for award of a contract, provided that the total evaluated price does not exceed the budget available for this requirement. In the event that the highest number of points is obtained by more than one responsive bid, the responsive bid with the lowest evaluated price will be recommended for award of a contract.

CONTRACTING AUTHORITY

Scott McRae Supply Team Leader

Public Works and Government Services Canada Acquisitions Branch Science Procurement Directorate Place du Portage III, 11C1 11 Laurier Street Gatineau, Québec K1A 0S5

Phone: (819) 956-1383 email: scott.mcrae@tpsgc-pwgsc.gc.ca

All enquiries must be submitted in writing to the Contracting Authority no later than ten (10) calendar days before the bid closing date. Delivery Date: Above-mentioned

The Crown retains the right to negotiate with suppliers on any procurement.

Documents may be submitted in either official language of Canada.