Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

NOTICE OF PROPOSED PROCUREMENT (NPP)

1. SOLICITATION #: 1000162382

2. CLOSING DATE: August 28 2014

2 CLOSING TIME and TIME ZONE: 3:00 p.m. EDT

This requirement is for the department of Health Canada.

4. TITLE: Bioinformatic Data Analyses for the Identification of Toxicity Mechanisms and Adverse Outcome Pathways related to Air Pollution Exposure

5. INTRODUCTION

The Inhalation Toxicology Laboratory (ITL) and Analytical Biochemistry and Proteomics Laboratory (ABPL) of Health Canada requires expert assistance with the bioinformatic analysis of high content proteomic mass spectral data derived from air pollution toxicology studies.

6. OBJECTIVES OF THE REQUIREMENT

The objective of this requirement is to complete expert bioinformatic analyses of the data generated in an investigation of the in vitro toxicity of ambient particulate matter impacted by source emissions on lung epithelial, mouse macrophage and human macrophage cell lines. The analyses will be used by Health Canada researchers to identify molecular changes relevant to air pollution toxicity in cell and animal models, and publish the results of the research in peer reviewed scientific publications.

7. SECURITY REQUIREMENT: There is no security associated with this requirement.

8. MANDATORY REQUIREMENTS

Attention Bidders: Please Write beside each of the criteria the relevant page number(s) from your proposal that addresses the requirement identified in the criteria.

M1 The Bidder must provide within their proposal a CV of the proposed resource that describes the capability to perform this work successfully.

M2 The Bidder must hold as a minimum a M.Sc. or Ph.D. in biology; and a graduate diploma or degree in bioinformatics. A copy of the certification/diploma must be included in the Bidders proposal.

M3 The Bidder must provide two references from previous work/projects that are similar to the work as outlined within this Statement of Work within their proposal. The references must be a Project Authority/Project Lead from a previous project.

For all referenced projects the Bidder must provide the following information

1. Name, phone number, and e-mail address of the client reference 2. Start and end dates of the project 3. Name of project and a brief description of the work involved 4. Role and length of involvement of the proposed resource on the project

*Note: Health Canada reserves the right to check references by contacting one or all of the references provided. Health Canada also reserves the right to reject a bidder should one or more of the references provided not be available within one week from completion of bid evaluation and if in checking references they do not confirm the resources work experience, quality of work and information provided by the bidder.

M4 The Bidder must provide a resource with at least 6 years of work experience from date of this RFP in conducting bioinformatic analyses of proteomic data.

Experience must be in months and years.

M5 The Bidder must have a minimum of five (5) years experience by the date of this RFP working as a bioinformatician in a proteomics laboratory.

Experience must be in month and years.

Address inquiries in writing to

Donna Pettit Senior Procurement and Contracting Officer Ottawa, ON K1A 0K9 Donna.pettit@hc-sc.gc.ca