Cr Single Cell Controller & Kit

Trade Agreement: NAFTA / CFTA / FTAs with Peru / Colombia / Panama / Korea Tendering Procedures: Generally only one firm has been invited to bid Non-Competitive Procurement Strategy: Exclusive Rights Comprehensive Land Claim Agreement: No Vendor Name and Address: 10x Genomics, Inc 7068 Koll Center Parkway, Ste 401 Pleasanton California United States 94566 Nature of Requirements:

ADVANCE CONTRACT AWARD NOTICE (ACAN)

An ACAN is a public notice indicating to the supplier community that a department or agency intends to award a contract for goods, services or construction to a pre-identified supplier, thereby allowing other suppliers to signal their interest in bidding, by submitting a statement of capabilities. If no supplier submits a statement of capabilities that meets the requirements set out in the ACAN, on or before the closing date stated in the ACAN, the contracting officer may then proceed with the award to the pre-identified supplier.

DEFINITION OF THE REQUIREMENT

- The Department of National Research Council of Canada has a requirement for the supply of 1 10X Genomics Chromium Single Cell Controller & Accessory Kit. - The product must comply with the following performance criteria.

The National Research Council of Canada (NRC) has a requirement to expand its current high-throughput sequencing capacity to include single cell sequencing. This expansion will enhance our capability in several applications, including the identification of gene expression profile and homogeneity of the universal stem cells and functional CAR-T cells created through CRISPER technology, for cell replacement in CNS diseases and cancer treatment, respectively. This will also improve the understanding of B cell profile during monoclonal antibody production, which will result in an increase of the value of antibodies and would increase the chances of successful transfer of those antibodies to the industries.

To achieve this specific capacity, the NRC requires a 10X Genomics Chromium Single Cell Controller & Accessory Kit.

CRITERIA FOR ASSESSMENT OF THE STATEMENT OF CAPABILITIES (MINIMUM ESSENTIAL REQUIREMENTS)

Any interested supplier must demonstrate by way of a statement of capabilities that its product meets the following requirements.

For interchangeability with the client’s existing systems and equipment, that is NRC’s in house NEXT-Seq sequencer and chemistry, the following requirements must be met in order to perform their research projects using superior quality technology:

- This product’s capture efficiency must meet a minimum requirement of 60 percent.

- The cost of cell capture to library must not exceed $0.15 to $1.50 (maximum) per cell approach.

- The proposed system for single cell RNA-seq and its associated reagents must offer various unique applications, including immune profiling for T and B cells, CNV, Feature barcoding and ATAC-Seq.

- Provide stand-alone, turn-key analysis pipelines and visualization software for novice and expert users alike

APPLICABILITY OF THE TRADE AGREEMENT(S) TO THE PROCUREMENT

This procurement is subject to the following trade agreement(s) : - Canadian Free Trade Agreement (CFTA) - North American Free Trade Agreement (NAFTA)

SET-ASIDE UNDER THE PROCUREMENT STRATEGY FOR ABORIGINAL BUSINESS

The Procurement Strategy for Aboriginal Business does not apply for this procurement.

COMPREHENSIVE LAND CLAIMS AGREEMENT(S)

This procurement is not subject to one of the CLCA’s.

JUSTIFICATION FOR THE PRE-IDENTIFIED SUPPLIER

Only 10X Genomics Chromium Single Cell Controller can satisfy all NRC requirements.

According to the client’s research, this product offers 65 percent capture efficiency which surpasses the minimum requirement of 60 percent.

In addition to single cell RNA-seq, the Chromium Single Cell Controller system and its associated reagents offer various unique applications, including immune profiling for T and B cells, CNV, Feature barcoding and ATAC-Seq.

Provide stand-alone, turn-key analysis pipelines and visualization software for novice and expert users alike.

The current sole source proposal is predicated on the requirement to enhance capability and throughput.

This item is purchased as an add-on to an existing system that belongs to 10x Genomics who has exclusive intellectual property rights to that system, and is being purchased for conformancy reasons.

GOVERNEMENT CONTRACTS REGULATIONS EXCEPTION(S)

The following exception to the Government Contracts Regulations is invoked for this procurement under subsection 6(d) "only one person is capable of performing the contract".

EXCLUSIONS AND/OR LIMITED TENDERING REASONS

The following exclusion(s) and/or limited tendering reasons are invoked under the: - Canadian Free Trade Agreement (CFTA) Article 513 b (ii) - North American Free Trade Agreement (NAFTA) Article 1016 2(b)

OWNERSHIP OF INTELLECTUAL PROPERTY N/A

PERIOD OF THE PROPOSED CONTRACT OR DELIVERY DATE

The proposed delivery date of the equipment is January 8, 2019, if at all possible.

COST ESTIMATE OF THE PROPOSED CONTRACT

The estimated value of the contract is between $60,000.00 and $100,000.00 (all applicable taxes included).

NAME AND ADRESS OF THE PRE-IDENTIFIED SUPPLIER

10 X Genomics, Inc. 7068 Koll Center Parkway, Suite 401 Pleasanton, California 94566 Unites States

SUPPLIERS' RIGHT TO SUBMIT A STATEMENT OF CAPABILITIES

Suppliers who consider themselves fully qualified and available to provide the goods, services or construction services described in the ACAN may submit a statement of capabilities in writing to the contact person identified in this notice on or before the closing date of this notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements.

CLOSING DATE FOR A SUBMISSION OF A STATEMENT OF CAPABILITIES

The closing date and time for accepting statements of capabilities is November 7, 2018 at 2:00 p.m. EST

INQUIRIES AND SUBMISSION OF STATEMENTS OF CAPABILITIES

Inquiries and statements of capabilities are to be directed to

Rachelle Constant Intern Officer

Place Bonaventure, portail sud-ouest 800, rue De La Gauchetière Ouest, bureau 7300 Montréal (Québec) H5A 1L6 Telephone: 514-210-7198 Facsimile: 514-496-3822 E-mail: rachelle.constant@tpsgc-pwgsc.gc.ca

Delivery Date: Above-mentioned

You are hereby notified that the government intends to negotiate with one firm only as identified above. Should you have any questions concerning this requirement, contact the contracting officer identified above.

An Advance Contract Award Notice (ACAN) allows departments and agencies to post a notice, for no less than fifteen (15) calendar days, indicating to the supplier community that it intends to award a good, service or construction contract to a pre-identified contractor. If no other supplier submits, on or before the closing date, a Statement of Capabilities that meets the requirements set out in the ACAN, the contracting authority may then proceed with the award. However, should a Statement of Capabilities be found to meet the requirements set out in the ACAN, then the contracting authority will proceed to a full tendering process.

Suppliers who consider themselves fully qualified and available to provide the services/goods described herein, may submit a statement of capabilities in writing to the contact person identified in this Notice on or before the closing date of this Notice. The statement of capabilities must clearly demonstrate how the supplier meets the advertised requirements.

The PWGSC file number, the contracting officer's name and the closing date of the ACAN must appear on the outside of the envelope in block letters or, in the case of a facsimile transmission, on the covering page.

The Crown retains the right to negotiate with suppliers on any procurement.

Documents may be submitted in either official language of Canada.